User Configuration > Administrative Templates > Microsoft Excel 2016 > Excel Options > General
User
HKCU\software\policies\microsoft\office\16.0\excel\options
This policy setting controls the default font for Excel. If you enable this policy setting, you can set the default font for Excel by specifing the font name and size seperated with a comma. Example: Arial, 10 If you disable or you do not configure this policy setting, Excel will use the default specified by the user.