User Configuration > Administrative Templates > Microsoft Outlook 2016 > Account Settings > Exchange
User
HKCU\software\policies\microsoft\office\16.0\outlook\rpc
This policy setting controls whether Outlook uses remote procedure call (RPC) encryption to communicate with Microsoft Exchange servers. If you enable this policy setting, Outlook uses RPC encryption when communicating with an Exchange server. Note - RPC encryption only encrypts the data from the Outlook client computer to the Exchange server. It does not encrypt the messages themselves as they traverse the Internet. If you disable or do not configure this policy setting, RPC encryption is still used by default. This setting allows you to override the corresponding per-profile setting.