User Configuration > Administrative Templates > Microsoft Outlook 2016 > Security > Cryptography
User
HKCU\software\policies\microsoft\office\16.0\outlook\security
This policy setting controls whether Outlook verifies the user's e-mail address with the address associated with the certificate used for signing. If you enable this policy setting, users can send messages signed with certificates that do not match their e-mail addresses. If you disable or do not configure this policy setting, Outlook verifies that the user's e-mail address matches the certificate being used for signing.