User Configuration > Administrative Templates > Microsoft Office 2016 > Miscellaneous
User
HKCU\software\policies\microsoft\office\16.0\common\fileio
This policy setting controls disabling caching when opening server-only files. Caching files helps Office speed up server-only file opens but could cause conflicts for organizations that rename files or change file contents directly on SharePoint. The cache is meant to improve performance so disabling it is expected to hurt performance.