Computer Configuration > Administrative Templates > Microsoft Edge > Content settings
Both
HKLM\Software\Policies\Microsoft\Edge
Define a list of sites, based on URL patterns, that can't ask the user to grant them access to a USB device. If you don't configure this policy, the global default value from the 'DefaultWebUsbGuardSetting' (Control use of the WebUSB API) policy (if set) or the user's personal configuration is used for all sites. URL patterns in this policy can't conflict with those configured in the 'WebUsbAskForUrls' (Allow WebUSB on specific sites) policy. You can't both allow and block a URL. For detailed information on valid url patterns, see https://go.microsoft.com/fwlink/?linkid=2095322. Example value: https://www.contoso.com [*.]contoso.edu