Computer Configuration > Administrative Templates > Microsoft Edge > Content settings
Both
HKLM\Software\Policies\Microsoft\Edge
Define a list of sites, based on URL patterns, that can ask the user for access to a USB device. If you don't configure this policy, the global default value from the 'DefaultWebUsbGuardSetting' (Control use of the WebUSB API) policy (if set) or the user's personal configuration is used for all sites. The URL patterns defined in this policy can't conflict with those configured in the 'WebUsbBlockedForUrls' (Block WebUSB on specific sites) policy - you can't both allow and block a URL. For detailed information on valid url patterns, please see https://go.microsoft.com/fwlink/?linkid=2095322 Example value: https://www.contoso.com [*.]contoso.edu