Computer Configuration > Administrative Templates > Microsoft Edge
Both
HKLM\Software\Policies\Microsoft\Edge
Controls whether WebRTC will respect the Windows OS routing table rules when making peer to peer connections, thus enabling split tunnel VPNs. If you disable this policy or don't configure it, WebRTC will not consider the routing table and may make peer to peer connections over any available network. If you enable this policy, WebRTC will prefer to make peer to peer connections using the indicated network interface for the remote address as indicated in the routing table. This policy is only available on Windows.