Computer Configuration > Administrative Templates > Microsoft Edge > SmartScreen settings
Both
HKLM\Software\Policies\Microsoft\Edge
Configure the list of Microsoft Defender SmartScreen trusted domains. This means: Microsoft Defender SmartScreen won't check for potentially malicious resources like phishing software and other malware if the source URLs match these domains. The Microsoft Defender SmartScreen download protection service won't check downloads hosted on these domains. If you enable this policy, Microsoft Defender SmartScreen trusts these domains. If you disable or don't set this policy, default Microsoft Defender SmartScreen protection is applied to all resources. This policy is available only on Windows instances that are joined to a Microsoft Active Directory domain, Windows 10/11 Pro or Enterprise instances that enrolled for device management, or macOS instances that are that are managed via MDM or joined to a domain via MCX. Note: If your organization has enabled Microsoft Defender for Endpoint, this policy and any allow list created with it will be ignored. You must configure your allow and block lists in Microsoft 365 Defender portal using Indicators (Settings > Endpoints > Indicators). Example value: mydomain.com myuniversity.edu