Computer Configuration > Administrative Templates > Microsoft Edge > Native Messaging
Both
HKLM\Software\Policies\Microsoft\Edge
Setting this policy specifies which native messaging hosts shouldn't be loaded. A deny list value of * means all native messaging hosts are denied unless they're explicitly allowed. If you leave this policy unset , Microsoft Edge loads all installed native messaging hosts. Example value: com.native.messaging.host.name1 com.native.messaging.host.name2